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Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through cell culture medium optimization

BACKGROUND: Recombinant therapeutic anti-CD20 monoclonal antibody (mAb) is used for the treatment of non-Hodgkin’s lymphoma, a common B cell lymphoma constituting 80% of all lymphomas. Anti-CD20 mAb contains an Fc-linked biantennary glycan. Although, anti-CD20 monoclonal antibodies are being increas...

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Detalles Bibliográficos
Autores principales:	Bheemareddy, Bala Reddy, Reddy, Prakash Narayana, Vemparala, Kranthi, Dirisala, Vijaya R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532503/ https://www.ncbi.nlm.nih.gov/pubmed/36194313 http://dx.doi.org/10.1186/s43141-022-00421-5

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