Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

Conjunctival melanoma (CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B (CuB). We found that CuB remarkably inhibited the proliferation of CM cells including CM-AS16, CRMM1, CRMM2 and CM2005....

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Detalles Bibliográficos
Autores principales: Wei, Jinlian, Chen, Xin, Li, Yongyun, Li, Ruoxi, Bao, Keting, Liao, Liang, Xie, Yuqing, Yang, Tiannuo, Zhu, Jin, Mao, Fei, Ni, Shuaishuai, Jia, Renbing, Xu, Xiaofang, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532536/
https://www.ncbi.nlm.nih.gov/pubmed/36213538
http://dx.doi.org/10.1016/j.apsb.2022.05.021

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