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Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human

Single units that are not related to the desired task can become related to the task by conditioning their firing rates. We theorized that, during conditioning of firing rates to a tone, (a) unrelated single units would be recruited to the task; (b) the recruitment would depend on the phase of the t...

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Autores principales: Kennedy, Philip, Cervantes, Andre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532552/
https://www.ncbi.nlm.nih.gov/pubmed/36211127
http://dx.doi.org/10.3389/fnhum.2022.864983
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author Kennedy, Philip
Cervantes, Andre J.
author_facet Kennedy, Philip
Cervantes, Andre J.
author_sort Kennedy, Philip
collection PubMed
description Single units that are not related to the desired task can become related to the task by conditioning their firing rates. We theorized that, during conditioning of firing rates to a tone, (a) unrelated single units would be recruited to the task; (b) the recruitment would depend on the phase of the task; (c) tones of different frequencies would produce different patterns of single unit recruitment. In our mute locked-in participant, we conditioned single units using tones of different frequencies emitted from a tone generator. The conditioning task had three phases: Listen to the tone for 20 s, then silently sing the tone for 10 s, with a prior control period of resting for 10 s. Twenty single units were recorded simultaneously while feedback of one of the twenty single units was made audible to the mute locked-in participant. The results indicate that (a) some of the non-audible single units were recruited during conditioning, (b) some were recruited differentially depending on the phase of the paradigm (listen, rest, or silent sing), and (c) single unit firing patterns were specific for different tone frequencies such that the tone could be recognized from the pattern of single unit firings. These data are important when conditioning single unit firings in brain-computer interfacing tasks because they provide evidence that increased numbers of previously unrelated single units can be incorporated into the task. This incorporation expands the bandwidth of the recorded single unit population and thus enhances the brain-computer interface. This is the first report of conditioning of single unit firings in a human participant with a brain to computer implant.
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spelling pubmed-95325522022-10-06 Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human Kennedy, Philip Cervantes, Andre J. Front Hum Neurosci Neuroscience Single units that are not related to the desired task can become related to the task by conditioning their firing rates. We theorized that, during conditioning of firing rates to a tone, (a) unrelated single units would be recruited to the task; (b) the recruitment would depend on the phase of the task; (c) tones of different frequencies would produce different patterns of single unit recruitment. In our mute locked-in participant, we conditioned single units using tones of different frequencies emitted from a tone generator. The conditioning task had three phases: Listen to the tone for 20 s, then silently sing the tone for 10 s, with a prior control period of resting for 10 s. Twenty single units were recorded simultaneously while feedback of one of the twenty single units was made audible to the mute locked-in participant. The results indicate that (a) some of the non-audible single units were recruited during conditioning, (b) some were recruited differentially depending on the phase of the paradigm (listen, rest, or silent sing), and (c) single unit firing patterns were specific for different tone frequencies such that the tone could be recognized from the pattern of single unit firings. These data are important when conditioning single unit firings in brain-computer interfacing tasks because they provide evidence that increased numbers of previously unrelated single units can be incorporated into the task. This incorporation expands the bandwidth of the recorded single unit population and thus enhances the brain-computer interface. This is the first report of conditioning of single unit firings in a human participant with a brain to computer implant. Frontiers Media S.A. 2022-09-21 /pmc/articles/PMC9532552/ /pubmed/36211127 http://dx.doi.org/10.3389/fnhum.2022.864983 Text en Copyright © 2022 Kennedy and Cervantes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kennedy, Philip
Cervantes, Andre J.
Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title_full Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title_fullStr Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title_full_unstemmed Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title_short Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human
title_sort recruitment and differential firing patterns of single units during conditioning to a tone in a mute locked-in human
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532552/
https://www.ncbi.nlm.nih.gov/pubmed/36211127
http://dx.doi.org/10.3389/fnhum.2022.864983
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