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Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research
There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current proces...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532574/ https://www.ncbi.nlm.nih.gov/pubmed/36212648 http://dx.doi.org/10.3389/fneur.2022.1000454 |
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author | Andersen, Christopher R. English, Shane W. Delaney, Anthony |
author_facet | Andersen, Christopher R. English, Shane W. Delaney, Anthony |
author_sort | Andersen, Christopher R. |
collection | PubMed |
description | There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining “what” to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda. |
format | Online Article Text |
id | pubmed-9532574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95325742022-10-06 Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research Andersen, Christopher R. English, Shane W. Delaney, Anthony Front Neurol Neurology There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining “what” to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda. Frontiers Media S.A. 2022-09-21 /pmc/articles/PMC9532574/ /pubmed/36212648 http://dx.doi.org/10.3389/fneur.2022.1000454 Text en Copyright © 2022 Andersen, English and Delaney. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Andersen, Christopher R. English, Shane W. Delaney, Anthony Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title_full | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title_fullStr | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title_full_unstemmed | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title_short | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
title_sort | made to measure—selecting outcomes in aneurysmal subarachnoid hemorrhage research |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532574/ https://www.ncbi.nlm.nih.gov/pubmed/36212648 http://dx.doi.org/10.3389/fneur.2022.1000454 |
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