Elevated plasma EDA fibronectin in primary myelofibrosis is determined by high allele burden of JAK2V617F mutation and strongly predicts splenomegaly progression

In primary myelofibrosis, extra-domain A fibronectin (EDA-FN), the result of alternative splicing of FN gene, sustains megakaryocyte proliferation and confers a pro-inflammatory phenotype to bone marrow cell niches. In this work we assessed the levels of circulating EDA-FN in plasma samples of 122 p...

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Detalles Bibliográficos
Autores principales: Malara, Alessandro, Gruppi, Cristian, Massa, Margherita, Tira, Maria Enrica, Rosti, Vittorio, Balduini, Alessandra, Barosi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532599/
https://www.ncbi.nlm.nih.gov/pubmed/36212480
http://dx.doi.org/10.3389/fonc.2022.987643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532599/
https://www.ncbi.nlm.nih.gov/pubmed/36212480
http://dx.doi.org/10.3389/fonc.2022.987643

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