Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines

The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased amount of O-linked Tn antigen (GalNAcα1-Ser/Thr) g...

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Detalles Bibliográficos
Autores principales: Huang, Shan, Thomsson, Kristina A., Jin, Chunsheng, Ryberg, Henrik, Das, Nabangshu, Struglics, André, Rolfson, Ola, Björkman, Lena I., Eisler, Thomas, Schmidt, Tannin A., Jay, Gregory D., Krawetz, Roman, Karlsson, Niclas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532613/
https://www.ncbi.nlm.nih.gov/pubmed/36213120
http://dx.doi.org/10.3389/fmolb.2022.942406

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