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Prognostic value of carboxyhemoglobin in pediatric intensive care unit

OBJECTIVES: To determine the carboxyhemoglobin (COHb) levels of the patients admitted to the pediatric intensive care unit and investigate its relationship with prognosis. METHODS: This retrospective observational study included patients aged one month to 18 years admitted to Mersin University Hospi...

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Autores principales: Alakaya, Mehmet, Arslankoylu, Ali Ertug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532639/
https://www.ncbi.nlm.nih.gov/pubmed/36246687
http://dx.doi.org/10.12669/pjms.38.7.5753
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author Alakaya, Mehmet
Arslankoylu, Ali Ertug
author_facet Alakaya, Mehmet
Arslankoylu, Ali Ertug
author_sort Alakaya, Mehmet
collection PubMed
description OBJECTIVES: To determine the carboxyhemoglobin (COHb) levels of the patients admitted to the pediatric intensive care unit and investigate its relationship with prognosis. METHODS: This retrospective observational study included patients aged one month to 18 years admitted to Mersin University Hospital pediatric intensive care unit from January 2020 to January 2021. Demographic characteristics, hospitalization causes, PRISM III, PELOD scores, hospitalization length, mechanical ventilation supports, transfusion needs, lactate and, SpCO levels of all patients were determined. SpCO levels of the excitus and surviving patients were compared, and the relationship with mortality was investigated. RESULTS: Total 365 patients were included in the study. The median carboxyhemoglobin level of the excitus patients was statistically significantly higher when compared to the level of the surviving patients [(1.8(1.4-2,4) vs 0.65(0-1) p<0.001]). For mortality prediction, the cut-off point for SpCO, which was determined with 100% sensitivity and 96.5% specificity, was calculated as 1.3. CONCLUSION: Since SpCO levels are increased in critically ill children and correlate with increased PICU mortality, SpCO may be a predictive marker for prognosis in PICU.
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spelling pubmed-95326392022-10-14 Prognostic value of carboxyhemoglobin in pediatric intensive care unit Alakaya, Mehmet Arslankoylu, Ali Ertug Pak J Med Sci Original Article OBJECTIVES: To determine the carboxyhemoglobin (COHb) levels of the patients admitted to the pediatric intensive care unit and investigate its relationship with prognosis. METHODS: This retrospective observational study included patients aged one month to 18 years admitted to Mersin University Hospital pediatric intensive care unit from January 2020 to January 2021. Demographic characteristics, hospitalization causes, PRISM III, PELOD scores, hospitalization length, mechanical ventilation supports, transfusion needs, lactate and, SpCO levels of all patients were determined. SpCO levels of the excitus and surviving patients were compared, and the relationship with mortality was investigated. RESULTS: Total 365 patients were included in the study. The median carboxyhemoglobin level of the excitus patients was statistically significantly higher when compared to the level of the surviving patients [(1.8(1.4-2,4) vs 0.65(0-1) p<0.001]). For mortality prediction, the cut-off point for SpCO, which was determined with 100% sensitivity and 96.5% specificity, was calculated as 1.3. CONCLUSION: Since SpCO levels are increased in critically ill children and correlate with increased PICU mortality, SpCO may be a predictive marker for prognosis in PICU. Professional Medical Publications 2022 /pmc/articles/PMC9532639/ /pubmed/36246687 http://dx.doi.org/10.12669/pjms.38.7.5753 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alakaya, Mehmet
Arslankoylu, Ali Ertug
Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title_full Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title_fullStr Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title_full_unstemmed Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title_short Prognostic value of carboxyhemoglobin in pediatric intensive care unit
title_sort prognostic value of carboxyhemoglobin in pediatric intensive care unit
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532639/
https://www.ncbi.nlm.nih.gov/pubmed/36246687
http://dx.doi.org/10.12669/pjms.38.7.5753
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