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Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

OBJECTIVES: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients METHODS: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October, 2021. One hundred a...

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Autores principales: Wahid, Maheen, Ali, Shabana, Yasin, Bilal, Farhat, Kulsoom, Noor, Mudassar, Syed, Fatima Tassadaq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532666/
https://www.ncbi.nlm.nih.gov/pubmed/36246694
http://dx.doi.org/10.12669/pjms.38.7.5585
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author Wahid, Maheen
Ali, Shabana
Yasin, Bilal
Farhat, Kulsoom
Noor, Mudassar
Syed, Fatima Tassadaq
author_facet Wahid, Maheen
Ali, Shabana
Yasin, Bilal
Farhat, Kulsoom
Noor, Mudassar
Syed, Fatima Tassadaq
author_sort Wahid, Maheen
collection PubMed
description OBJECTIVES: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients METHODS: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October, 2021. One hundred and twenty pregnant women undergoing cesarean section, were enrolled in the study via non probability convenience sampling, and divided into three groups containing 40 participants each based on the type of antiemetic premedication they received, if any: Group N were those not requiring antiemetic premedication, Group O consisted of those given ondansetron 4mg, and Group G had those receiving 3mg granisetron, 15 minutes prior to administration of spinal anaesthesia. Systolic blood pressures and heart rates were recorded before and at multiple intervals after spinal anaesthesia was administered. Episodes of hypotension and bradycardia were recorded. Requirement of phenylephrine and atropine as rescue drugs was recorded for each participant. RESULTS: There was a statistically significant difference in incidence of hypotension among the three groups (p value <0.001), with both drugs being superior to the control group (p value <0.001 for both), and 3mg granisetron being superior to 4mg ondansetron (p value <0.001). As for incidence of bradycardia, ondansetron and granisetron were superior to control group (p value 0.03 and <0.001 respectively), but there was no significant difference between the two drug groups (p value 0.094). CONCLUSION: High dose granisetron (3mg) is superior to low dose ondansetron (4mg) in preventing hemodynamic fluctuations induced by spinal anaesthesia.
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spelling pubmed-95326662022-10-14 Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients Wahid, Maheen Ali, Shabana Yasin, Bilal Farhat, Kulsoom Noor, Mudassar Syed, Fatima Tassadaq Pak J Med Sci Original Article OBJECTIVES: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients METHODS: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October, 2021. One hundred and twenty pregnant women undergoing cesarean section, were enrolled in the study via non probability convenience sampling, and divided into three groups containing 40 participants each based on the type of antiemetic premedication they received, if any: Group N were those not requiring antiemetic premedication, Group O consisted of those given ondansetron 4mg, and Group G had those receiving 3mg granisetron, 15 minutes prior to administration of spinal anaesthesia. Systolic blood pressures and heart rates were recorded before and at multiple intervals after spinal anaesthesia was administered. Episodes of hypotension and bradycardia were recorded. Requirement of phenylephrine and atropine as rescue drugs was recorded for each participant. RESULTS: There was a statistically significant difference in incidence of hypotension among the three groups (p value <0.001), with both drugs being superior to the control group (p value <0.001 for both), and 3mg granisetron being superior to 4mg ondansetron (p value <0.001). As for incidence of bradycardia, ondansetron and granisetron were superior to control group (p value 0.03 and <0.001 respectively), but there was no significant difference between the two drug groups (p value 0.094). CONCLUSION: High dose granisetron (3mg) is superior to low dose ondansetron (4mg) in preventing hemodynamic fluctuations induced by spinal anaesthesia. Professional Medical Publications 2022 /pmc/articles/PMC9532666/ /pubmed/36246694 http://dx.doi.org/10.12669/pjms.38.7.5585 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wahid, Maheen
Ali, Shabana
Yasin, Bilal
Farhat, Kulsoom
Noor, Mudassar
Syed, Fatima Tassadaq
Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title_full Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title_fullStr Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title_full_unstemmed Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title_short Granisetron versus Ondansetron: Comparison of 5HT(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
title_sort granisetron versus ondansetron: comparison of 5ht(3) antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532666/
https://www.ncbi.nlm.nih.gov/pubmed/36246694
http://dx.doi.org/10.12669/pjms.38.7.5585
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