Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I(−/−) iPSCs for β cell replacement

Induced pluripotent stem cells (iPSCs) represent a source from which β cells can be derived for diabetes replacement therapy. However, their application may be hindered by immune-mediated responses. Although abrogation of major histocompatibility complex class I (MHC-I) can address this issue, it ma...

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Detalles Bibliográficos
Autores principales: Chimienti, Raniero, Baccega, Tania, Torchio, Silvia, Manenti, Fabio, Pellegrini, Silvia, Cospito, Alessandro, Amabile, Angelo, Lombardo, Marta Tiffany, Monti, Paolo, Sordi, Valeria, Lombardo, Angelo, Malnati, Mauro, Piemonti, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532846/
https://www.ncbi.nlm.nih.gov/pubmed/36170817
http://dx.doi.org/10.1016/j.celrep.2022.111423

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