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Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications. Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes. However, the impact of...

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Detalles Bibliográficos
Autores principales:	Fashe, Muluneh M., Fallon, John K., Miner, Taryn A., Tiley, Jacqueline B., Smith, Philip C., Lee, Craig R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532936/ https://www.ncbi.nlm.nih.gov/pubmed/36210832 http://dx.doi.org/10.3389/fphar.2022.1004010

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