Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

SNAT2 (SLC38A2) is a sodium-dependent neutral amino acid transporter, which is important for the accumulation of amino acids as nutrients, the maintenance of cellular osmolarity, and the activation of mTORC1. It also provides net glutamine for glutaminolysis and consequently presents as a potential...

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Detalles Bibliográficos
Autores principales: Gauthier-Coles, Gregory, Bröer, Angelika, McLeod, Malcolm Donald, George, Amee J., Hannan, Ross D., Bröer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532951/
https://www.ncbi.nlm.nih.gov/pubmed/36210829
http://dx.doi.org/10.3389/fphar.2022.963066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532951/
https://www.ncbi.nlm.nih.gov/pubmed/36210829
http://dx.doi.org/10.3389/fphar.2022.963066

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