Cargando…

Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients

Background Dilated perivascular spaces (dPVS) in the basal ganglia are associated with aging, vascular risk factors, and other magnetic resonance imaging (MRI) markers of cerebral small vessel disease (cSVD). While high blood lipids are a well-demonstrated risk factor for large artery atherosclerosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Diker, Sevda, Gelener, Pınar, Erem, Aysegül, Balyemez, Ugurcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532960/
https://www.ncbi.nlm.nih.gov/pubmed/36225408
http://dx.doi.org/10.7759/cureus.28783
_version_ 1784802236849717248
author Diker, Sevda
Gelener, Pınar
Erem, Aysegül
Balyemez, Ugurcan
author_facet Diker, Sevda
Gelener, Pınar
Erem, Aysegül
Balyemez, Ugurcan
author_sort Diker, Sevda
collection PubMed
description Background Dilated perivascular spaces (dPVS) in the basal ganglia are associated with aging, vascular risk factors, and other magnetic resonance imaging (MRI) markers of cerebral small vessel disease (cSVD). While high blood lipids are a well-demonstrated risk factor for large artery atherosclerosis, their role in cSVD remains largely elusive. Methods We evaluated lipid profiles, cardiovascular risk factors, and brain MRI findings in patients with ischemic stroke or transient ischemic attack. We analyzed the extent of dPVS, cerebral microbleed (CMB), and cerebral white matter hyperintensities (WMHs) as MRI indices of cSVD and investigated associations of dPVS with lipid parameters and other cSVD indices. Results Our study enrolled 173 patients with ischemic stroke or transient ischemic attack. The mean age was 68.38±14.31 (range 35-99) years, and 57.8% (n=100) of patients were male. dPVSwere detected in 97% (n=168) of the patients. Among the whole population, half of the patients (n=87) had moderate to severe dPVS. According to the univariate analysis, age, hypertension, previous antiaggregant and/or anticoagulant use, and the high-density lipoprotein to low-density lipoprotein (HDL/LDL) ratio but not other lipid profiles, cerebral microbleed load, and cerebral white matter hyperintensities severity were found to be positively associated with dPVS number in the basal ganglia. After multivariate logistic regression analysis, only age and WMH severity remained statistically significant. Conclusions dPVS are closely associated with other cSVD subtypes and aging. The studied lipid indices were not independently associated with moderate to severe dPVS in basal ganglia in ischemic stroke patients. The association of each lipid and HDL/LDL ratio needs to be further studied with a larger number of participants.
format Online
Article
Text
id pubmed-9532960
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-95329602022-10-11 Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients Diker, Sevda Gelener, Pınar Erem, Aysegül Balyemez, Ugurcan Cureus Neurology Background Dilated perivascular spaces (dPVS) in the basal ganglia are associated with aging, vascular risk factors, and other magnetic resonance imaging (MRI) markers of cerebral small vessel disease (cSVD). While high blood lipids are a well-demonstrated risk factor for large artery atherosclerosis, their role in cSVD remains largely elusive. Methods We evaluated lipid profiles, cardiovascular risk factors, and brain MRI findings in patients with ischemic stroke or transient ischemic attack. We analyzed the extent of dPVS, cerebral microbleed (CMB), and cerebral white matter hyperintensities (WMHs) as MRI indices of cSVD and investigated associations of dPVS with lipid parameters and other cSVD indices. Results Our study enrolled 173 patients with ischemic stroke or transient ischemic attack. The mean age was 68.38±14.31 (range 35-99) years, and 57.8% (n=100) of patients were male. dPVSwere detected in 97% (n=168) of the patients. Among the whole population, half of the patients (n=87) had moderate to severe dPVS. According to the univariate analysis, age, hypertension, previous antiaggregant and/or anticoagulant use, and the high-density lipoprotein to low-density lipoprotein (HDL/LDL) ratio but not other lipid profiles, cerebral microbleed load, and cerebral white matter hyperintensities severity were found to be positively associated with dPVS number in the basal ganglia. After multivariate logistic regression analysis, only age and WMH severity remained statistically significant. Conclusions dPVS are closely associated with other cSVD subtypes and aging. The studied lipid indices were not independently associated with moderate to severe dPVS in basal ganglia in ischemic stroke patients. The association of each lipid and HDL/LDL ratio needs to be further studied with a larger number of participants. Cureus 2022-09-05 /pmc/articles/PMC9532960/ /pubmed/36225408 http://dx.doi.org/10.7759/cureus.28783 Text en Copyright © 2022, Diker et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Diker, Sevda
Gelener, Pınar
Erem, Aysegül
Balyemez, Ugurcan
Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title_full Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title_fullStr Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title_full_unstemmed Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title_short Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients
title_sort association of dilated perivascular spaces with lipid indices in ischemic stroke patients
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532960/
https://www.ncbi.nlm.nih.gov/pubmed/36225408
http://dx.doi.org/10.7759/cureus.28783
work_keys_str_mv AT dikersevda associationofdilatedperivascularspaceswithlipidindicesinischemicstrokepatients
AT gelenerpınar associationofdilatedperivascularspaceswithlipidindicesinischemicstrokepatients
AT eremaysegul associationofdilatedperivascularspaceswithlipidindicesinischemicstrokepatients
AT balyemezugurcan associationofdilatedperivascularspaceswithlipidindicesinischemicstrokepatients