Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING E3 ubiquitin ligase complex responsible for the degradation of RAS GTPases. In parallel, dysregulated LZTR1 expression via aberrant splicing...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Sisi, Vedula, Rahul S., Cuevas-Navarro, Antonio, Lu, Bin, Hogg, Simon J., Wang, Eric, Benbarche, Salima, Knorr, Katherine, Kim, Won Jun, Stanley, Robert F., Cho, Hana, Erickson, Caroline, Singer, Michael, Cui, Dan, Tittley, Steven, Durham, Benjamin H., Pavletich, Tatiana S., Fiala, Elise, Walsh, Michael F., Inoue, Daichi, Monette, Sebastien, Taylor, Justin, Rosen, Neal, McCormick, Frank, Lindsley, R. Coleman, Castel, Pau, Abdel-Wahab, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533010/
https://www.ncbi.nlm.nih.gov/pubmed/35904492
http://dx.doi.org/10.1158/2159-8290.CD-21-1631

Ejemplares similares

Ejemplares similares