Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance

In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia rendered offspring vulnerable to glucose intolerance due to insufficient TET3‐mediated 5‐methylcytosine oxidation and DNA demethylation, resulting in hypermethylation and reduction of insulin‐secreting ge...

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Detalles Bibliográficos
Autores principales: Wu, Xiumei, Xu, Suowen, Weng, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533033/
https://www.ncbi.nlm.nih.gov/pubmed/35839128
http://dx.doi.org/10.1111/jdi.13885
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author Wu, Xiumei
Xu, Suowen
Weng, Jianping
author_facet Wu, Xiumei
Xu, Suowen
Weng, Jianping
author_sort Wu, Xiumei
collection PubMed
description In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia rendered offspring vulnerable to glucose intolerance due to insufficient TET3‐mediated 5‐methylcytosine oxidation and DNA demethylation, resulting in hypermethylation and reduction of insulin‐secreting genes.[Image: see text]
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spelling pubmed-95330332022-10-11 Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance Wu, Xiumei Xu, Suowen Weng, Jianping J Diabetes Investig Commentary In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia rendered offspring vulnerable to glucose intolerance due to insufficient TET3‐mediated 5‐methylcytosine oxidation and DNA demethylation, resulting in hypermethylation and reduction of insulin‐secreting genes.[Image: see text] John Wiley and Sons Inc. 2022-07-29 2022-10 /pmc/articles/PMC9533033/ /pubmed/35839128 http://dx.doi.org/10.1111/jdi.13885 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentary
Wu, Xiumei
Xu, Suowen
Weng, Jianping
Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title_full Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title_fullStr Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title_full_unstemmed Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title_short Hyperglycemia‐mediated oocyte TET3 insufficiency predisposes offspring to glucose intolerance
title_sort hyperglycemia‐mediated oocyte tet3 insufficiency predisposes offspring to glucose intolerance
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533033/
https://www.ncbi.nlm.nih.gov/pubmed/35839128
http://dx.doi.org/10.1111/jdi.13885
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AT xusuowen hyperglycemiamediatedoocytetet3insufficiencypredisposesoffspringtoglucoseintolerance
AT wengjianping hyperglycemiamediatedoocytetet3insufficiencypredisposesoffspringtoglucoseintolerance

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