Cargando…

Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy

AIMS/INTRODUCTION: We aimed to evaluate and compare continuous glucose monitoring system (CGMS)‐based glycemic parameters in women in early pregnancy (<20 weeks of gestation) who were classified as: (i) gestational diabetes mellitus (GDM) by the International Association of Diabetes and Pregnancy...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Yashdeep, Singh, Charandeep, Goyal, Alpesh, Mani, Kalaivani, Bharti, Juhi, Singhal, Seema, Kachhawa, Garima, Kulshrestha, Vidushi, Kumari, Rajesh, Mahey, Reeta, Sharma, Jai B, Malhotra, Neena, Bhatla, Neerja, Khadgawat, Rajesh, Tandon, Nikhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533043/
https://www.ncbi.nlm.nih.gov/pubmed/35661435
http://dx.doi.org/10.1111/jdi.13865
_version_ 1784802256272490496
author Gupta, Yashdeep
Singh, Charandeep
Goyal, Alpesh
Mani, Kalaivani
Bharti, Juhi
Singhal, Seema
Kachhawa, Garima
Kulshrestha, Vidushi
Kumari, Rajesh
Mahey, Reeta
Sharma, Jai B
Malhotra, Neena
Bhatla, Neerja
Khadgawat, Rajesh
Tandon, Nikhil
author_facet Gupta, Yashdeep
Singh, Charandeep
Goyal, Alpesh
Mani, Kalaivani
Bharti, Juhi
Singhal, Seema
Kachhawa, Garima
Kulshrestha, Vidushi
Kumari, Rajesh
Mahey, Reeta
Sharma, Jai B
Malhotra, Neena
Bhatla, Neerja
Khadgawat, Rajesh
Tandon, Nikhil
author_sort Gupta, Yashdeep
collection PubMed
description AIMS/INTRODUCTION: We aimed to evaluate and compare continuous glucose monitoring system (CGMS)‐based glycemic parameters in women in early pregnancy (<20 weeks of gestation) who were classified as: (i) gestational diabetes mellitus (GDM) by the International Association of Diabetes and Pregnancy Study Groups (IADPSG), but normoglycemia by alternate (UK National Institute for Health and Care Excellence, Canadian Diabetes Association and Diabetes in Pregnancy Study group of India) criteria; and (ii) normoglycemia by both (IADPSG and alternate) criteria. MATERIAL AND METHODS: In this cross‐sectional study, eligible women underwent standard 75‐g oral glucose tolerance test, followed by the placement of a CGMS. Glycemia‐related parameters were calculated using the standard approach for CGMS data in pregnancy. RESULTS: We enrolled 96 women at 14.0 ± 3.2 weeks of gestation. Of the women diagnosed as GDM by IADPSG criteria, 34.2%, 26.3% and 44.7% were classified as normoglycemic by UK National Institute for Health and Care Excellence, Canadian Diabetes Association and Diabetes in Pregnancy Study group of India criteria, respectively. Mean 1‐h postprandial glucose and time above range were significantly higher in women who were GDM by IADPSG, but normoglycemia by Canadian Diabetes Association criteria, compared with women with normoglycemia using both criteria. Similarly, mean 1‐h postprandial glucose, 2‐h postprandial glucose, peak postprandial glucose, 1‐h postprandial glucose excursion and time above range were significantly higher in women who were not identified as GDM by the UK National Institute for Health and Care Excellence criteria. Finally, women missed by the Diabetes in Pregnancy Study group of India criteria had significantly higher mean 1‐h postprandial glucose, 2‐h postprandial glucose, peak postprandial glucose, postprandial glucose excursion, 24‐h glucose and time above range parameters. CONCLUSIONS: More than one‐quarter of women diagnosed as GDM by IADPSG criteria are not identified by alternate criteria. Such women are significantly different from normoglycemic women in terms of several CGMS‐based glycemic parameters of clinical significance.
format Online
Article
Text
id pubmed-9533043
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95330432022-10-11 Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy Gupta, Yashdeep Singh, Charandeep Goyal, Alpesh Mani, Kalaivani Bharti, Juhi Singhal, Seema Kachhawa, Garima Kulshrestha, Vidushi Kumari, Rajesh Mahey, Reeta Sharma, Jai B Malhotra, Neena Bhatla, Neerja Khadgawat, Rajesh Tandon, Nikhil J Diabetes Investig Articles AIMS/INTRODUCTION: We aimed to evaluate and compare continuous glucose monitoring system (CGMS)‐based glycemic parameters in women in early pregnancy (<20 weeks of gestation) who were classified as: (i) gestational diabetes mellitus (GDM) by the International Association of Diabetes and Pregnancy Study Groups (IADPSG), but normoglycemia by alternate (UK National Institute for Health and Care Excellence, Canadian Diabetes Association and Diabetes in Pregnancy Study group of India) criteria; and (ii) normoglycemia by both (IADPSG and alternate) criteria. MATERIAL AND METHODS: In this cross‐sectional study, eligible women underwent standard 75‐g oral glucose tolerance test, followed by the placement of a CGMS. Glycemia‐related parameters were calculated using the standard approach for CGMS data in pregnancy. RESULTS: We enrolled 96 women at 14.0 ± 3.2 weeks of gestation. Of the women diagnosed as GDM by IADPSG criteria, 34.2%, 26.3% and 44.7% were classified as normoglycemic by UK National Institute for Health and Care Excellence, Canadian Diabetes Association and Diabetes in Pregnancy Study group of India criteria, respectively. Mean 1‐h postprandial glucose and time above range were significantly higher in women who were GDM by IADPSG, but normoglycemia by Canadian Diabetes Association criteria, compared with women with normoglycemia using both criteria. Similarly, mean 1‐h postprandial glucose, 2‐h postprandial glucose, peak postprandial glucose, 1‐h postprandial glucose excursion and time above range were significantly higher in women who were not identified as GDM by the UK National Institute for Health and Care Excellence criteria. Finally, women missed by the Diabetes in Pregnancy Study group of India criteria had significantly higher mean 1‐h postprandial glucose, 2‐h postprandial glucose, peak postprandial glucose, postprandial glucose excursion, 24‐h glucose and time above range parameters. CONCLUSIONS: More than one‐quarter of women diagnosed as GDM by IADPSG criteria are not identified by alternate criteria. Such women are significantly different from normoglycemic women in terms of several CGMS‐based glycemic parameters of clinical significance. John Wiley and Sons Inc. 2022-06-21 2022-10 /pmc/articles/PMC9533043/ /pubmed/35661435 http://dx.doi.org/10.1111/jdi.13865 Text en © 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Gupta, Yashdeep
Singh, Charandeep
Goyal, Alpesh
Mani, Kalaivani
Bharti, Juhi
Singhal, Seema
Kachhawa, Garima
Kulshrestha, Vidushi
Kumari, Rajesh
Mahey, Reeta
Sharma, Jai B
Malhotra, Neena
Bhatla, Neerja
Khadgawat, Rajesh
Tandon, Nikhil
Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title_full Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title_fullStr Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title_full_unstemmed Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title_short Continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by International Association of Diabetes and Pregnancy Study Groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
title_sort continuous glucose monitoring system profile of women diagnosed as gestational diabetes mellitus by international association of diabetes and pregnancy study groups criteria and labeled as normoglycemic by alternate criteria in early pregnancy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533043/
https://www.ncbi.nlm.nih.gov/pubmed/35661435
http://dx.doi.org/10.1111/jdi.13865
work_keys_str_mv AT guptayashdeep continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT singhcharandeep continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT goyalalpesh continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT manikalaivani continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT bhartijuhi continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT singhalseema continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT kachhawagarima continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT kulshresthavidushi continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT kumarirajesh continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT maheyreeta continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT sharmajaib continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT malhotraneena continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT bhatlaneerja continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT khadgawatrajesh continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy
AT tandonnikhil continuousglucosemonitoringsystemprofileofwomendiagnosedasgestationaldiabetesmellitusbyinternationalassociationofdiabetesandpregnancystudygroupscriteriaandlabeledasnormoglycemicbyalternatecriteriainearlypregnancy