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Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs

Cannabidiol (CBD) containing dog food and treats are widely commercially available, mirroring the growing popularity of CBD as a supplement for humans. Despite this, experimental evidence of the safety and efficacy of long-term oral exposure in dogs is lacking. The purpose of this study was to addre...

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Autores principales: Bradley, Sophie, Young, Scott, Bakke, Anne Marie, Holcombe, Lucy, Waller, Daniel, Hunt, Alysia, Pinfold, Kathleen, Watson, Phillip, Logan, Darren W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533147/
https://www.ncbi.nlm.nih.gov/pubmed/36213402
http://dx.doi.org/10.3389/fvets.2022.977457
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author Bradley, Sophie
Young, Scott
Bakke, Anne Marie
Holcombe, Lucy
Waller, Daniel
Hunt, Alysia
Pinfold, Kathleen
Watson, Phillip
Logan, Darren W.
author_facet Bradley, Sophie
Young, Scott
Bakke, Anne Marie
Holcombe, Lucy
Waller, Daniel
Hunt, Alysia
Pinfold, Kathleen
Watson, Phillip
Logan, Darren W.
author_sort Bradley, Sophie
collection PubMed
description Cannabidiol (CBD) containing dog food and treats are widely commercially available, mirroring the growing popularity of CBD as a supplement for humans. Despite this, experimental evidence of the safety and efficacy of long-term oral exposure in dogs is lacking. The purpose of this study was to address the gap in knowledge around the longer-term suitability and tolerance of a broad-spectrum CBD (THC-free) distillate in clinically healthy dogs. The study was a randomized, placebo-controlled, and blinded study where one group of twenty dogs received daily CBD capsules at a dose of 4 mg/kg of body weight (BW) for a period of 6 months. The control group of twenty dogs received placebo capsules. A comprehensive suite of physiological health measures was performed throughout the study at baseline, and after 2, 4, 10, 18, and 26 weeks of exposure, followed by 4 weeks of washout. CBD concentrations were measured at the same cadence in plasma, feces and urine. Health measures included biochemistry, hematology, urinalysis, in addition to fortnightly veterinary examinations, twice daily well-being observations, and a daily quality-of-life survey. Biochemistry and hematology showed no clinically significant alterations apart from a transient elevation in alkaline phosphatase (ALP) in just over half of the dogs receiving CBD. This elevation was observed in the absence of concurrent elevations of other liver parameters, and without any adverse effects on health and wellbeing. Furthermore, bone alkaline phosphatase (BALP) was simultaneously elevated with a significant, strong (r > 0.9) positive correlation between the two measures, suggesting that the elevation of total ALP was at least partly due to the bone-derived isoform. This study provides evidence that a once-daily oral dose of 4 mg CBD/kg BW is well tolerated in clinically healthy dogs for a duration of 6-months.
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spelling pubmed-95331472022-10-06 Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs Bradley, Sophie Young, Scott Bakke, Anne Marie Holcombe, Lucy Waller, Daniel Hunt, Alysia Pinfold, Kathleen Watson, Phillip Logan, Darren W. Front Vet Sci Veterinary Science Cannabidiol (CBD) containing dog food and treats are widely commercially available, mirroring the growing popularity of CBD as a supplement for humans. Despite this, experimental evidence of the safety and efficacy of long-term oral exposure in dogs is lacking. The purpose of this study was to address the gap in knowledge around the longer-term suitability and tolerance of a broad-spectrum CBD (THC-free) distillate in clinically healthy dogs. The study was a randomized, placebo-controlled, and blinded study where one group of twenty dogs received daily CBD capsules at a dose of 4 mg/kg of body weight (BW) for a period of 6 months. The control group of twenty dogs received placebo capsules. A comprehensive suite of physiological health measures was performed throughout the study at baseline, and after 2, 4, 10, 18, and 26 weeks of exposure, followed by 4 weeks of washout. CBD concentrations were measured at the same cadence in plasma, feces and urine. Health measures included biochemistry, hematology, urinalysis, in addition to fortnightly veterinary examinations, twice daily well-being observations, and a daily quality-of-life survey. Biochemistry and hematology showed no clinically significant alterations apart from a transient elevation in alkaline phosphatase (ALP) in just over half of the dogs receiving CBD. This elevation was observed in the absence of concurrent elevations of other liver parameters, and without any adverse effects on health and wellbeing. Furthermore, bone alkaline phosphatase (BALP) was simultaneously elevated with a significant, strong (r > 0.9) positive correlation between the two measures, suggesting that the elevation of total ALP was at least partly due to the bone-derived isoform. This study provides evidence that a once-daily oral dose of 4 mg CBD/kg BW is well tolerated in clinically healthy dogs for a duration of 6-months. Frontiers Media S.A. 2022-09-21 /pmc/articles/PMC9533147/ /pubmed/36213402 http://dx.doi.org/10.3389/fvets.2022.977457 Text en Copyright © 2022 Bradley, Young, Bakke, Holcombe, Waller, Hunt, Pinfold, Watson and Logan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Bradley, Sophie
Young, Scott
Bakke, Anne Marie
Holcombe, Lucy
Waller, Daniel
Hunt, Alysia
Pinfold, Kathleen
Watson, Phillip
Logan, Darren W.
Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title_full Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title_fullStr Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title_full_unstemmed Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title_short Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
title_sort long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533147/
https://www.ncbi.nlm.nih.gov/pubmed/36213402
http://dx.doi.org/10.3389/fvets.2022.977457
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