Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage

We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2(ORF3a), Mycobacte...

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Detalles Bibliográficos
Autores principales: Jia, Jingyue, Wang, Fulong, Bhujabal, Zambarlal, Peters, Ryan, Mudd, Michal, Duque, Thabata, Allers, Lee, Javed, Ruheena, Salemi, Michelle, Behrends, Christian, Phinney, Brett, Johansen, Terje, Deretic, Vojo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533235/
https://www.ncbi.nlm.nih.gov/pubmed/36179369
http://dx.doi.org/10.1083/jcb.202207091

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