Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights

Emergence of antimicrobial resistance has become a great threat to human species as there is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR by initiating research and developing new novel antimicrobial agents. Among phytoconstituents, Quinoline (nitrogen contain...

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Detalles Bibliográficos
Autores principales: Kumar, Nitish, Khanna, Aanchal, Kaur, Komalpreet, Kaur, Harmandeep, Sharma, Anchal, Bedi, Preet Mohinder Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Comprehensive Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533295/
https://www.ncbi.nlm.nih.gov/pubmed/36197551
http://dx.doi.org/10.1007/s11030-022-10537-y
Descripción
Sumario:Emergence of antimicrobial resistance has become a great threat to human species as there is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR by initiating research and developing new novel antimicrobial agents. Among phytoconstituents, Quinoline (nitrogen containing heterocyclic) have played a wide role in providing new bioactive molecules. So, this review provides rational approaches, design strategies, structure activity relationship and mechanistic insights of newly developed quinoline derivatives as antimicrobial agents. GRAPHICAL ABSTRACT: [Image: see text]

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