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Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells

[Image: see text] Hypoxic areas are present in the majority of solid tumors, and hypoxia is associated with resistance to therapies and poor outcomes. A transmembrane protein that is upregulated by tumor cells that have adapted to hypoxic conditions is carbonic anhydrase IX (CAIX). Therefore, noninv...

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Detalles Bibliográficos
Autores principales:	van Lith, Sanne A.M., Huizing, Fokko J., Franssen, Gerben M., Hoeben, Bianca A.W., Lok, Jasper, Doulkeridou, Sofia, Boerman, Otto C., Gotthardt, Martin, van Bergen en Henegouwen, Paul M.P., Bussink, Johan, Heskamp, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533306/ https://www.ncbi.nlm.nih.gov/pubmed/35044182 http://dx.doi.org/10.1021/acs.molpharmaceut.1c00841

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