SMN controls neuromuscular junction integrity through U7 snRNP

The neuromuscular junction (NMJ) is an essential synapse whose loss is a key hallmark of the neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that activity of the SMA-determining SMN protein in the assembly of U7 small nuclear ribonucleoprotein (snRNP)—which functions in the 3′...

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Detalles Bibliográficos
Autores principales: Tisdale, Sarah, Van Alstyne, Meaghan, Simon, Christian M., Mentis, George Z., Pellizzoni, Livio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533342/
https://www.ncbi.nlm.nih.gov/pubmed/36130491
http://dx.doi.org/10.1016/j.celrep.2022.111393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533342/
https://www.ncbi.nlm.nih.gov/pubmed/36130491
http://dx.doi.org/10.1016/j.celrep.2022.111393

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