A distinct subpopulation of leukemia initiating cells in acute precursor B lymphoblastic leukemia: quiescent phenotype and unique transcriptomic profile

In leukemia, a distinct subpopulation of cancer-initiating cells called leukemia stem cells (LSCs) is believed to drive population expansion and tumor growth. Failing to eliminate LSCs may result in disease relapse regardless of the amount of non-LSCs destroyed. The first step in targeting and elimi...

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Detalles Bibliográficos
Autores principales: Lee, Alex Q., Konishi, Hiroaki, Duong, Connie, Yoshida, Sakiko, Davis, Ryan R., Van Dyke, Jonathan E., Ijiri, Masami, McLaughlin, Bridget, Kim, Kyoungmi, Li, Yueju, Beckett, Laurel, Nitin, Nitin, McPherson, John D., Tepper, Clifford G., Satake, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533407/
https://www.ncbi.nlm.nih.gov/pubmed/36212452
http://dx.doi.org/10.3389/fonc.2022.972323

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