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The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications
Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability for fluorescent bioimaging applicatio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533410/ https://www.ncbi.nlm.nih.gov/pubmed/36320587 http://dx.doi.org/10.1039/d2sc03136a |
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author | Zhao, Xuan Zhang, Fan Lei, Zuhai |
author_facet | Zhao, Xuan Zhang, Fan Lei, Zuhai |
author_sort | Zhao, Xuan |
collection | PubMed |
description | Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability for fluorescent bioimaging applications. Very recently, remarkable advances have been made in the development of NIR-II polymethine fluorophores with improved optical performance, mainly including tunable fluorescence, improved brightness, improved water solubility and stability. In this review, we summarize the recent research advances in molecular tailoring design strategies of NIR-II polymethine fluorophores, and then emphasize the representative bioimaging and biosensing applications. The potential challenges and perspectives of NIR-II polymethine fluorophores in this emerging field are also discussed. This review may provide guidance and reference for further development of high-performance NIR-II polymethine fluorophores to boost their clinical translation in the future. |
format | Online Article Text |
id | pubmed-9533410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95334102022-10-31 The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications Zhao, Xuan Zhang, Fan Lei, Zuhai Chem Sci Chemistry Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their high molar extinction coefficients, intensive fluorescence brightness, and flexible wavelength tunability for fluorescent bioimaging applications. Very recently, remarkable advances have been made in the development of NIR-II polymethine fluorophores with improved optical performance, mainly including tunable fluorescence, improved brightness, improved water solubility and stability. In this review, we summarize the recent research advances in molecular tailoring design strategies of NIR-II polymethine fluorophores, and then emphasize the representative bioimaging and biosensing applications. The potential challenges and perspectives of NIR-II polymethine fluorophores in this emerging field are also discussed. This review may provide guidance and reference for further development of high-performance NIR-II polymethine fluorophores to boost their clinical translation in the future. The Royal Society of Chemistry 2022-08-27 /pmc/articles/PMC9533410/ /pubmed/36320587 http://dx.doi.org/10.1039/d2sc03136a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Zhao, Xuan Zhang, Fan Lei, Zuhai The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title | The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title_full | The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title_fullStr | The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title_full_unstemmed | The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title_short | The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications |
title_sort | pursuit of polymethine fluorophores with nir-ii emission and high brightness for in vivo applications |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533410/ https://www.ncbi.nlm.nih.gov/pubmed/36320587 http://dx.doi.org/10.1039/d2sc03136a |
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