Cargando…
The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes
BACKGROUND: Wound healing is a complex process including hemostasis, inflammation, proliferation, and remodeling during which an orchestrated array of biological and molecular events occurs to promote skin regeneration. Abnormalities in each step of the wound healing process lead to reparative rathe...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533440/ https://www.ncbi.nlm.nih.gov/pubmed/35696989 http://dx.doi.org/10.1159/000524990 |
_version_ | 1784802346502455296 |
---|---|
author | Amjadian, Sara Moradi, Sharif Mohammadi, Parvaneh |
author_facet | Amjadian, Sara Moradi, Sharif Mohammadi, Parvaneh |
author_sort | Amjadian, Sara |
collection | PubMed |
description | BACKGROUND: Wound healing is a complex process including hemostasis, inflammation, proliferation, and remodeling during which an orchestrated array of biological and molecular events occurs to promote skin regeneration. Abnormalities in each step of the wound healing process lead to reparative rather than regenerative responses, thereby driving the formation of cutaneous scar. Patients suffering from scars represent serious health problems such as contractures, functional and esthetic concerns as well as painful, thick, and itchy complications, which generally decrease the quality of life and impose high medical costs. Therefore, therapies reducing cutaneous scarring are necessary to improve patients' rehabilitation. SUMMARY: Current approaches to remove scars, including surgical and nonsurgical methods, are not efficient enough, which is in principle due to our limited knowledge about underlying mechanisms of pathological as well as the physiological wound healing process. Thus, therapeutic interventions focused on basic science including genetic and epigenetic knowledge are recently taken into consideration as promising approaches for scar management since they have the potential to provide targeted therapies and improve the conventional treatments as well as present opportunities for combination therapy. In this review, we highlight the recent advances in skin regenerative medicine through genetic and epigenetic approaches to achieve novel insights for the development of safe, efficient, and reproducible therapies and discuss promising approaches for scar management. KEY MESSAGE: Genetic and epigenetic regulatory switches are promising targets for scar management, provided the associated challenges are to be addressed. |
format | Online Article Text |
id | pubmed-9533440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-95334402022-10-06 The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes Amjadian, Sara Moradi, Sharif Mohammadi, Parvaneh Skin Pharmacol Physiol Review Article BACKGROUND: Wound healing is a complex process including hemostasis, inflammation, proliferation, and remodeling during which an orchestrated array of biological and molecular events occurs to promote skin regeneration. Abnormalities in each step of the wound healing process lead to reparative rather than regenerative responses, thereby driving the formation of cutaneous scar. Patients suffering from scars represent serious health problems such as contractures, functional and esthetic concerns as well as painful, thick, and itchy complications, which generally decrease the quality of life and impose high medical costs. Therefore, therapies reducing cutaneous scarring are necessary to improve patients' rehabilitation. SUMMARY: Current approaches to remove scars, including surgical and nonsurgical methods, are not efficient enough, which is in principle due to our limited knowledge about underlying mechanisms of pathological as well as the physiological wound healing process. Thus, therapeutic interventions focused on basic science including genetic and epigenetic knowledge are recently taken into consideration as promising approaches for scar management since they have the potential to provide targeted therapies and improve the conventional treatments as well as present opportunities for combination therapy. In this review, we highlight the recent advances in skin regenerative medicine through genetic and epigenetic approaches to achieve novel insights for the development of safe, efficient, and reproducible therapies and discuss promising approaches for scar management. KEY MESSAGE: Genetic and epigenetic regulatory switches are promising targets for scar management, provided the associated challenges are to be addressed. S. Karger AG 2022-06-13 /pmc/articles/PMC9533440/ /pubmed/35696989 http://dx.doi.org/10.1159/000524990 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by/4.0/This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher. |
spellingShingle | Review Article Amjadian, Sara Moradi, Sharif Mohammadi, Parvaneh The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title | The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title_full | The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title_fullStr | The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title_full_unstemmed | The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title_short | The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes |
title_sort | emerging therapeutic targets for scar management: genetic and epigenetic landscapes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533440/ https://www.ncbi.nlm.nih.gov/pubmed/35696989 http://dx.doi.org/10.1159/000524990 |
work_keys_str_mv | AT amjadiansara theemergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes AT moradisharif theemergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes AT mohammadiparvaneh theemergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes AT amjadiansara emergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes AT moradisharif emergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes AT mohammadiparvaneh emergingtherapeutictargetsforscarmanagementgeneticandepigeneticlandscapes |