Cargando…

SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity

BACKGROUND: Multiple sclerosis (MS) is a chronic, debilitating condition characterized by CNS autoimmunity stemming from a complex etiology involving both environmental and genetic factors. Our current understanding of MS points to dysregulation of the immune system as the pathogenic culprit, howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Connell, Patrick, Blake, Maja K., Godbehere, Sarah, Amalfitano, Andrea, Aldhamen, Yasser A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533612/ https://www.ncbi.nlm.nih.gov/pubmed/36199066 http://dx.doi.org/10.1186/s12974-022-02594-9

Ejemplares similares

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses
por: Blake, Maja K., et al.
Publicado: (2022)

Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth
por: O'Connell, Patrick, et al.
Publicado: (2021)

Vaccine Platforms Combining Circumsporozoite Protein and Potent Immune Modulators, rEA or EAT-2, Paradoxically Result in Opposing Immune Responses
por: Schuldt, Nathaniel J., et al.
Publicado: (2011)

SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond
por: O’Connell, Patrick, et al.
Publicado: (2019)

Fundamentals to therapeutics: Epigenetic modulation of CD8(+) T Cell exhaustion in the tumor microenvironment
por: Blake, Maja K., et al.
Publicado: (2023)

Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and Adenovirus (Ad5) immune mice
por: Schuldt, Nathaniel J, et al.
Publicado: (2012)

In vitro Infection of Primary Human Monocytes with HIV-1
por: O’Connell, Patrick, et al.
Publicado: (2019)

CR1/2 is an important suppressor of Adenovirus induced innate immune responses and is required for induction of neutralizing antibodies
por: Seregin, Sergey S., et al.
Publicado: (2009)

Immune Recognition of Gene Transfer Vectors: Focus on Adenovirus as a Paradigm
por: Aldhamen, Yasser Ali, et al.
Publicado: (2011)

Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response
por: Aldhamen, Yasser A., et al.
Publicado: (2013)

Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors
por: Wang, Ninghai, et al.
Publicado: (2015)

TRIF Is a Critical Negative Regulator of TLR Agonist Mediated Activation of Dendritic Cells In Vivo
por: Seregin, Sergey S., et al.
Publicado: (2011)

CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development
por: Huang, Bonnie, et al.
Publicado: (2016)

A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target
por: Appledorn, Daniel M., et al.
Publicado: (2010)

SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population
por: Xia, Guodong, et al.
Publicado: (2022)

Treatment of multiple myeloma with the immunostimulatory SLAMF7 antibody elotuzumab
por: Einsele, Hermann, et al.
Publicado: (2016)

Clinical impact of serum soluble SLAMF7 in multiple myeloma
por: Ishibashi, Mariko, et al.
Publicado: (2018)

Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma
por: Friend, Reed, et al.
Publicado: (2017)

SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis
por: Wu, Yongjian, et al.
Publicado: (2023)

SLAMF7 as a Promising Immunotherapeutic Target in Multiple Myeloma Treatments
por: Chu, Emily, et al.
Publicado: (2023)

Responses to Microbial Challenges by SLAMF Receptors
por: van Driel, Boaz Job, et al.
Publicado: (2016)

ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
por: Pepelyayeva, Yuliya, et al.
Publicado: (2018)

Migration of Myeloid Cells during Inflammation Is Differentially Regulated by the Cell Surface Receptors Slamf1 and Slamf8
por: Wang, Guoxing, et al.
Publicado: (2015)

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
por: He, Yuan, et al.
Publicado: (2019)

Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
por: Buhler, Lillian A, et al.
Publicado: (2009)

The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi
por: Calderón, Jossela, et al.
Publicado: (2012)

CRISPR-Mediated Slamf1(Δ/Δ) Slamf5(Δ/Δ) Slamf6(Δ/Δ) Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects
por: Hu, Joyce K., et al.
Publicado: (2016)

SLAMF6 compartmentalization enhances T cell functions
por: Gartshteyn, Yevgeniya, et al.
Publicado: (2022)

SLAMF Receptor Expression Identifies an Immune Signature That Characterizes Systemic Lupus Erythematosus
por: Humbel, Morgane, et al.
Publicado: (2022)

Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases
por: Magnusson, Louise, et al.
Publicado: (2020)

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity
por: Bearoff, Frank, et al.
Publicado: (2016)

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
por: Montgomery, Theresa L., et al.
Publicado: (2022)

Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases
por: Sun, Lin, et al.
Publicado: (2021)

SLAMF6 clustering is required to augment T cell activation
por: Dragovich, Matthew A., et al.
Publicado: (2019)

Integrated DNA methylation and gene expression analysis identifies SLAMF7 as a key regulator of atherosclerosis
por: Xia, Zhangyong, et al.
Publicado: (2018)

Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma
por: Campbell, Kerry S., et al.
Publicado: (2018)

Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns
por: Danhof, Sophia, et al.
Publicado: (2021)

Strong prognostic value of SLAMF7 protein expression in patients with lymph node-positive breast cancer
por: Assidi, Mourad
Publicado: (2022)

P1025: A PILOT STUDY OF THE ANTI-SLAMF7 MONOCLONAL ANTIBODY, ELOTUZUMAB, IN PATIENTS WITH MYELOFIBROSIS.
por: Bose, Prithviraj, et al.
Publicado: (2023)

SLAMF8, a potential new immune checkpoint molecule, is associated with the prognosis of colorectal cancer
por: Zhang, Yaping, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_il5lv3jcugceh117b4cvk7bsv0