Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report

An 80-year-old Japanese male patient with Behçet’s disease presented with a seven-day history of fever, cough, and progressive shortness of breath after receiving a second dose of the BNT16B2b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). The initial diagnosis was community-acquired pneumonia, and antib...

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Detalles Bibliográficos
Autores principales: Kojima, Yuichi, Takeyabu, Kimihiro, Satoh, Miki, Konno, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2022
Materias:
Case Reports and Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533633/
https://www.ncbi.nlm.nih.gov/pubmed/36212609
http://dx.doi.org/10.1016/j.clinpr.2022.100204
Descripción
Sumario:An 80-year-old Japanese male patient with Behçet’s disease presented with a seven-day history of fever, cough, and progressive shortness of breath after receiving a second dose of the BNT16B2b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). The initial diagnosis was community-acquired pneumonia, and antibiotic treatment was started but proved ineffective. Twenty days after onset, his platelet count was significantly decreased. We suspected vaccine-induced pneumonitis and thrombocytopenia. After administration of prednisolone and intravenous immunoglobulin, and platelet transfusions, his platelet count normalized. The pneumonia symptoms improved three weeks after onset. Herein, we also summarize previous reports of cases of pneumonitis and thrombocytopenia associated with SARS-CoV-2 vaccination.

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