Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report

An 80-year-old Japanese male patient with Behçet’s disease presented with a seven-day history of fever, cough, and progressive shortness of breath after receiving a second dose of the BNT16B2b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). The initial diagnosis was community-acquired pneumonia, and antib...

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Autores principales: Kojima, Yuichi, Takeyabu, Kimihiro, Satoh, Miki, Konno, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2022
Materias:
Case Reports and Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533633/
https://www.ncbi.nlm.nih.gov/pubmed/36212609
http://dx.doi.org/10.1016/j.clinpr.2022.100204
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author Kojima, Yuichi
Takeyabu, Kimihiro
Satoh, Miki
Konno, Satoshi
author_facet Kojima, Yuichi
Takeyabu, Kimihiro
Satoh, Miki
Konno, Satoshi
author_sort Kojima, Yuichi
collection PubMed
description An 80-year-old Japanese male patient with Behçet’s disease presented with a seven-day history of fever, cough, and progressive shortness of breath after receiving a second dose of the BNT16B2b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). The initial diagnosis was community-acquired pneumonia, and antibiotic treatment was started but proved ineffective. Twenty days after onset, his platelet count was significantly decreased. We suspected vaccine-induced pneumonitis and thrombocytopenia. After administration of prednisolone and intravenous immunoglobulin, and platelet transfusions, his platelet count normalized. The pneumonia symptoms improved three weeks after onset. Herein, we also summarize previous reports of cases of pneumonitis and thrombocytopenia associated with SARS-CoV-2 vaccination.
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spelling pubmed-95336332022-10-05 Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report Kojima, Yuichi Takeyabu, Kimihiro Satoh, Miki Konno, Satoshi Clin Infect Pract Case Reports and Series An 80-year-old Japanese male patient with Behçet’s disease presented with a seven-day history of fever, cough, and progressive shortness of breath after receiving a second dose of the BNT16B2b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). The initial diagnosis was community-acquired pneumonia, and antibiotic treatment was started but proved ineffective. Twenty days after onset, his platelet count was significantly decreased. We suspected vaccine-induced pneumonitis and thrombocytopenia. After administration of prednisolone and intravenous immunoglobulin, and platelet transfusions, his platelet count normalized. The pneumonia symptoms improved three weeks after onset. Herein, we also summarize previous reports of cases of pneumonitis and thrombocytopenia associated with SARS-CoV-2 vaccination. The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2022-11 2022-10-05 /pmc/articles/PMC9533633/ /pubmed/36212609 http://dx.doi.org/10.1016/j.clinpr.2022.100204 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Reports and Series
Kojima, Yuichi
Takeyabu, Kimihiro
Satoh, Miki
Konno, Satoshi
Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title_full Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title_fullStr Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title_full_unstemmed Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title_short Thrombocytopenia and pneumonitis associated with BNT16B2b2 mRNA COVID-19 vaccine: A case report
title_sort thrombocytopenia and pneumonitis associated with bnt16b2b2 mrna covid-19 vaccine: a case report
topic Case Reports and Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533633/
https://www.ncbi.nlm.nih.gov/pubmed/36212609
http://dx.doi.org/10.1016/j.clinpr.2022.100204
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