Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model

Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene‐edited mouse model that expresses a VAV1 mutant protein that recapitulates the signal...

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Detalles Bibliográficos
Autores principales: Robles‐Valero, Javier, Fernández‐Nevado, Lucía, Cuadrado, Myriam, Lorenzo‐Martín, Luis Francisco, Fernández‐Pisonero, Isabel, Abad, Antonio, Redín, Esther, Montuenga, Luis, Martín‐Zanca, Dionisio, Bigas, Anna, Mallo, Moisés, Dosil, Mercedes, Bustelo, Xosé R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533688/
https://www.ncbi.nlm.nih.gov/pubmed/35895495
http://dx.doi.org/10.1002/1878-0261.13295

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