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Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia

Heparin Induced Thrombocytopenia (HIT) is a life threatening condition which is caused due to antibody formation following exposure to heparin or heparin products. It occurs due to the formation of Platelet Factor 4 antibodies (PF4). HIT is classified into 3 categories based on the duration between...

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Autores principales: Chittal, Abhinandan R., Kumar, Ajay, Rao, Shiavax J., Lakra, Pallavi, Nacu, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Greater Baltimore Medical Center 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533806/
https://www.ncbi.nlm.nih.gov/pubmed/36262902
http://dx.doi.org/10.55729/2000-9666.1081
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author Chittal, Abhinandan R.
Kumar, Ajay
Rao, Shiavax J.
Lakra, Pallavi
Nacu, Natalia
author_facet Chittal, Abhinandan R.
Kumar, Ajay
Rao, Shiavax J.
Lakra, Pallavi
Nacu, Natalia
author_sort Chittal, Abhinandan R.
collection PubMed
description Heparin Induced Thrombocytopenia (HIT) is a life threatening condition which is caused due to antibody formation following exposure to heparin or heparin products. It occurs due to the formation of Platelet Factor 4 antibodies (PF4). HIT is classified into 3 categories based on the duration between heparin exposure and onset of drop in platelet counts. A less common form of HIT is delayed onset HIT which occurs more than 9 days after exposure to heparin or heparin products. In this report we would like to present a rare case of delayed onset HIT which occurred in our patient who presented with rhabdomyolysis and Non ST elevation myocardial infraction (NSTEMI); which resulted in limb ischemia which needed to be treated by amputation of the affected area. We also highlight further management of patients who have thrombotic disease in the setting of HIT and review literature of how heparin or heparin products can be reintroduced in such patient who cannot be managed by other anticoagulation.
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spelling pubmed-95338062022-10-18 Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia Chittal, Abhinandan R. Kumar, Ajay Rao, Shiavax J. Lakra, Pallavi Nacu, Natalia J Community Hosp Intern Med Perspect Case Report Heparin Induced Thrombocytopenia (HIT) is a life threatening condition which is caused due to antibody formation following exposure to heparin or heparin products. It occurs due to the formation of Platelet Factor 4 antibodies (PF4). HIT is classified into 3 categories based on the duration between heparin exposure and onset of drop in platelet counts. A less common form of HIT is delayed onset HIT which occurs more than 9 days after exposure to heparin or heparin products. In this report we would like to present a rare case of delayed onset HIT which occurred in our patient who presented with rhabdomyolysis and Non ST elevation myocardial infraction (NSTEMI); which resulted in limb ischemia which needed to be treated by amputation of the affected area. We also highlight further management of patients who have thrombotic disease in the setting of HIT and review literature of how heparin or heparin products can be reintroduced in such patient who cannot be managed by other anticoagulation. Greater Baltimore Medical Center 2022-07-04 /pmc/articles/PMC9533806/ /pubmed/36262902 http://dx.doi.org/10.55729/2000-9666.1081 Text en © 2022 Greater Baltimore Medical Center https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ).
spellingShingle Case Report
Chittal, Abhinandan R.
Kumar, Ajay
Rao, Shiavax J.
Lakra, Pallavi
Nacu, Natalia
Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title_full Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title_fullStr Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title_full_unstemmed Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title_short Arterial and Venous Thrombosis From Delayed-Onset Heparin-Induced Thrombocytopenia
title_sort arterial and venous thrombosis from delayed-onset heparin-induced thrombocytopenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533806/
https://www.ncbi.nlm.nih.gov/pubmed/36262902
http://dx.doi.org/10.55729/2000-9666.1081
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