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Virulence differences between monkeypox virus isolates from West Africa and the Congo basin

Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the...

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Autores principales: Chen, Nanhai, Li, Guiyun, Liszewski, M. Kathryn, Atkinson, John P., Jahrling, Peter B., Feng, Zehua, Schriewer, Jill, Buck, Charles, Wang, Chunlin, Lefkowitz, Elliot J., Esposito, Joseph J., Harms, Tiara, Damon, Inger K., Roper, Rachel L., Upton, Chris, Buller, R. Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534023/
https://www.ncbi.nlm.nih.gov/pubmed/16023693
http://dx.doi.org/10.1016/j.virol.2005.05.030
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author Chen, Nanhai
Li, Guiyun
Liszewski, M. Kathryn
Atkinson, John P.
Jahrling, Peter B.
Feng, Zehua
Schriewer, Jill
Buck, Charles
Wang, Chunlin
Lefkowitz, Elliot J.
Esposito, Joseph J.
Harms, Tiara
Damon, Inger K.
Roper, Rachel L.
Upton, Chris
Buller, R. Mark L.
author_facet Chen, Nanhai
Li, Guiyun
Liszewski, M. Kathryn
Atkinson, John P.
Jahrling, Peter B.
Feng, Zehua
Schriewer, Jill
Buck, Charles
Wang, Chunlin
Lefkowitz, Elliot J.
Esposito, Joseph J.
Harms, Tiara
Damon, Inger K.
Roper, Rachel L.
Upton, Chris
Buller, R. Mark L.
author_sort Chen, Nanhai
collection PubMed
description Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate.
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spelling pubmed-95340232022-10-07 Virulence differences between monkeypox virus isolates from West Africa and the Congo basin Chen, Nanhai Li, Guiyun Liszewski, M. Kathryn Atkinson, John P. Jahrling, Peter B. Feng, Zehua Schriewer, Jill Buck, Charles Wang, Chunlin Lefkowitz, Elliot J. Esposito, Joseph J. Harms, Tiara Damon, Inger K. Roper, Rachel L. Upton, Chris Buller, R. Mark L. Virology Article Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate. Elsevier Inc. 2005-09-15 2005-07-14 /pmc/articles/PMC9534023/ /pubmed/16023693 http://dx.doi.org/10.1016/j.virol.2005.05.030 Text en Copyright © 2005 Elsevier Inc. All rights reserved. Elsevier has created a Monkeypox Information Center in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Article
Chen, Nanhai
Li, Guiyun
Liszewski, M. Kathryn
Atkinson, John P.
Jahrling, Peter B.
Feng, Zehua
Schriewer, Jill
Buck, Charles
Wang, Chunlin
Lefkowitz, Elliot J.
Esposito, Joseph J.
Harms, Tiara
Damon, Inger K.
Roper, Rachel L.
Upton, Chris
Buller, R. Mark L.
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title_full Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title_fullStr Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title_full_unstemmed Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title_short Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
title_sort virulence differences between monkeypox virus isolates from west africa and the congo basin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534023/
https://www.ncbi.nlm.nih.gov/pubmed/16023693
http://dx.doi.org/10.1016/j.virol.2005.05.030
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