Genome-wide fetalization of enhancer architecture in heart disease

Heart disease is associated with re-expression of key transcription factors normally active only during prenatal development of the heart. However, the impact of this reactivation on the regulatory landscape in heart disease is unclear. Here, we use RNA-seq and ChIP-seq targeting a histone modificat...

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Detalles Bibliográficos
Autores principales: Spurrell, Cailyn H., Barozzi, Iros, Kosicki, Michael, Mannion, Brandon J., Blow, Matthew J., Fukuda-Yuzawa, Yoko, Slaven, Neil, Afzal, Sarah Y., Akiyama, Jennifer A., Afzal, Veena, Tran, Stella, Plajzer-Frick, Ingrid, Novak, Catherine S., Kato, Momoe, Lee, Elizabeth A., Garvin, Tyler H., Pham, Quan T., Kronshage, Anne N., Lisgo, Steven, Bristow, James, Cappola, Thomas P., Morley, Michael P., Margulies, Kenneth B., Pennacchio, Len A., Dickel, Diane E., Visel, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534044/
https://www.ncbi.nlm.nih.gov/pubmed/36130500
http://dx.doi.org/10.1016/j.celrep.2022.111400

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