First-in-human study to evaluate safety, tolerability, and immunogenicity of heterologous regimens using the multivalent filovirus vaccines Ad26.Filo and MVA-BN-Filo administered in different sequences and schedules: A randomized, controlled study

BACKGROUND: Though clinically similar, Ebola virus disease and Marburg virus disease are caused by different viruses. Of the 30 documented outbreaks of these diseases in sub-Saharan Africa, eight were major outbreaks (≥200 cases; five caused by Zaire ebolavirus [EBOV], two by Sudan ebolavirus [SUDV]...

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Detalles Bibliográficos
Autores principales: Bockstal, Viki, Shukarev, Georgi, McLean, Chelsea, Goldstein, Neil, Bart, Stephan, Gaddah, Auguste, Anumenden, Dickson, Stoop, Jeroen N., Marit de Groot, Anne, Pau, Maria G., Hendriks, Jenny, De Rosa, Stephen C., Cohen, Kristen W., McElrath, M. Juliana, Callendret, Benoit, Luhn, Kerstin, Douoguih, Macaya, Robinson, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534391/
https://www.ncbi.nlm.nih.gov/pubmed/36197845
http://dx.doi.org/10.1371/journal.pone.0274906

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