The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing

The evolutionarily conserved RNA helicase DDX6 is a central player in post-transcriptional regulation, but its role during embryogenesis remains elusive. We here show that DDX6 enables proper cell lineage specification from pluripotent cells by analyzing Ddx6 knockout (KO) mouse embryos and employin...

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Detalles Bibliográficos
Autores principales: Kim, Jessica, Muraoka, Masafumi, Okada, Hajime, Toyoda, Atsushi, Ajima, Rieko, Saga, Yumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534413/
https://www.ncbi.nlm.nih.gov/pubmed/36197846
http://dx.doi.org/10.1371/journal.pgen.1009967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534413/
https://www.ncbi.nlm.nih.gov/pubmed/36197846
http://dx.doi.org/10.1371/journal.pgen.1009967

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