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Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells

Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and tumor progression. HCMV proteins were shown to regulate the key processes involved in tumorigenesis. While HCMV as an oncogenic factor just came...

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Detalles Bibliográficos
Autores principales: Vinogradskaya, G. R., Ivanov, A. V., Kushch, A. A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534468/
https://www.ncbi.nlm.nih.gov/pubmed/36217337
http://dx.doi.org/10.1134/S0026893322050132
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author Vinogradskaya, G. R.
Ivanov, A. V.
Kushch, A. A
author_facet Vinogradskaya, G. R.
Ivanov, A. V.
Kushch, A. A
author_sort Vinogradskaya, G. R.
collection PubMed
description Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and tumor progression. HCMV proteins were shown to regulate the key processes involved in tumorigenesis. While HCMV as an oncogenic factor just came into focus, its ability to promote tumor progression is generally recognized. The review discusses the viral factors and cell molecular pathways that affect the resistance of cancer cells to therapy. CMV inhibits apoptosis of tumor cells, that not only promotes tumor progression, but also reduces the sensitivity of cells to antitumor therapy. Autophagy was found to facilitate either cell survival or cell death in different tumor cells. In leukemia cells, HCMV induces a “protective” autophagy that suppresses apoptosis. Viral factors that mediate drug resistance and their interactions with key cell death pathways are necessary to further investigate in order to develop agents that can restore the tumor sensitivity to anticancer drugs.
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spelling pubmed-95344682022-10-06 Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells Vinogradskaya, G. R. Ivanov, A. V. Kushch, A. A Mol Biol Virial Infections: Replication and Pathogenesis Mechanisms to Therapy Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and tumor progression. HCMV proteins were shown to regulate the key processes involved in tumorigenesis. While HCMV as an oncogenic factor just came into focus, its ability to promote tumor progression is generally recognized. The review discusses the viral factors and cell molecular pathways that affect the resistance of cancer cells to therapy. CMV inhibits apoptosis of tumor cells, that not only promotes tumor progression, but also reduces the sensitivity of cells to antitumor therapy. Autophagy was found to facilitate either cell survival or cell death in different tumor cells. In leukemia cells, HCMV induces a “protective” autophagy that suppresses apoptosis. Viral factors that mediate drug resistance and their interactions with key cell death pathways are necessary to further investigate in order to develop agents that can restore the tumor sensitivity to anticancer drugs. Pleiades Publishing 2022-10-05 2022 /pmc/articles/PMC9534468/ /pubmed/36217337 http://dx.doi.org/10.1134/S0026893322050132 Text en © Pleiades Publishing, Inc. 2022, ISSN 0026-8933, Molecular Biology, 2022, Vol. 56, No. 5, pp. 668–683. © Pleiades Publishing, Inc., 2022.Russian Text © The Author(s), 2022, published in Molekulyarnaya Biologiya, 2022, Vol. 56, No. 5, pp. 732–750. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Virial Infections: Replication and Pathogenesis Mechanisms to Therapy
Vinogradskaya, G. R.
Ivanov, A. V.
Kushch, A. A
Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title_full Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title_fullStr Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title_full_unstemmed Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title_short Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
title_sort mechanisms of survival of cytomegalovirus-infected tumor cells
topic Virial Infections: Replication and Pathogenesis Mechanisms to Therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534468/
https://www.ncbi.nlm.nih.gov/pubmed/36217337
http://dx.doi.org/10.1134/S0026893322050132
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