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Stable iPSC-derived NKX2-1(+) lung bud tip progenitor organoids give rise to airway and alveolar cell types

Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in the airways and alveoli. This work aimed to develop an iPSC organoid model enriched with NKX2-1(+) BTP-like cells. Building on previous studies, we optimized a directed differentiation paradigm to gener...

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Detalles Bibliográficos
Autores principales:	Hein, Renee F. C., Conchola, Ansley S., Fine, Alexis S., Xiao, Zhiwei, Frum, Tristan, Brastrom, Lindy K., Akinwale, Mayowa A., Childs, Charlie J., Tsai, Yu-Hwai, Holloway, Emily M., Huang, Sha, Mahoney, John, Heemskerk, Idse, Spence, Jason R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Stem Cells and Regeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534489/ https://www.ncbi.nlm.nih.gov/pubmed/36039869 http://dx.doi.org/10.1242/dev.200693

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