Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma

The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited because of innate resistance to treatment. We identified elevated expression of the histone methyltransferase EZH2 as a hallmark of aggressive UCa and hypothesized that EZH2 inhibition, via a small-molecule cataly...

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Detalles Bibliográficos
Autores principales: Piunti, Andrea, Meghani, Khyati, Yu, Yanni, Robertson, A. Gordon, Podojil, Joseph R., McLaughlin, Kimberly A., You, Zonghao, Fantini, Damiano, Chiang, MingYi, Luo, Yi, Wang, Lu, Heyen, Nathan, Qian, Jun, Miller, Stephen D., Shilatifard, Ali, Meeks, Joshua J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534493/
https://www.ncbi.nlm.nih.gov/pubmed/36197969
http://dx.doi.org/10.1126/sciadv.abo8043

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