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CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS

An imbalance in the activities of the Polycomb and Trithorax complexes underlies numerous human pathologies, including cancer. The BRCA1 associated protein-1 (BAP1) deubiquitinase negatively regulates Polycomb activity and recruits the Trithorax histone H3K4 methyltransferase, mixed-lineage leukemia...

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Detalles Bibliográficos
Autores principales:	Zhao, Zibo, Rendleman, Emily Jane, Szczepanski, Aileen Patricia, Morgan, Marc Alard, Wang, Lu, Shilatifard, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534506/ https://www.ncbi.nlm.nih.gov/pubmed/36197977 http://dx.doi.org/10.1126/sciadv.add3339

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