KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma

BACKGROUND: Uveal Melanoma (UM) is a potentially lethal cancer, and epigenetics may participate in the regulation of MEK resistance. This study is aimed at targeting the epigenetic kinase to overcome the resistance to MEK inhibitor. METHOD: We developed the 92.1 and OMM1 MEK-inhibitor resistant cell...

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Detalles Bibliográficos
Autores principales: Zhang, Hongjun, Liu, Xiangnan, Chen, Yong'an, Xu, Rui, He, Shengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534647/
https://www.ncbi.nlm.nih.gov/pubmed/36212716
http://dx.doi.org/10.1155/2022/1556485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534647/
https://www.ncbi.nlm.nih.gov/pubmed/36212716
http://dx.doi.org/10.1155/2022/1556485

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