Cargando…
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice
Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534756/ https://www.ncbi.nlm.nih.gov/pubmed/36171430 http://dx.doi.org/10.1038/s41593-022-01170-x |
| _version_ | 1784802617061277696 |
|---|---|
| author | Auguste, Yohan S. S. Ferro, Austin Kahng, Jessica A. Xavier, Andre M. Dixon, Jessica R. Vrudhula, Uma Nichitiu, Anne-Sarah Rosado, Daniele Wee, Tse-Luen Pedmale, Ullas V. Cheadle, Lucas |
| author_facet | Auguste, Yohan S. S. Ferro, Austin Kahng, Jessica A. Xavier, Andre M. Dixon, Jessica R. Vrudhula, Uma Nichitiu, Anne-Sarah Rosado, Daniele Wee, Tse-Luen Pedmale, Ullas V. Cheadle, Lucas |
| author_sort | Auguste, Yohan S. S. |
| collection | PubMed |
| description | Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement. Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis. |
| format | Online Article Text |
| id | pubmed-9534756 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95347562022-10-07 Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice Auguste, Yohan S. S. Ferro, Austin Kahng, Jessica A. Xavier, Andre M. Dixon, Jessica R. Vrudhula, Uma Nichitiu, Anne-Sarah Rosado, Daniele Wee, Tse-Luen Pedmale, Ullas V. Cheadle, Lucas Nat Neurosci Brief Communication Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement. Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis. Nature Publishing Group US 2022-09-28 2022 /pmc/articles/PMC9534756/ /pubmed/36171430 http://dx.doi.org/10.1038/s41593-022-01170-x Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Auguste, Yohan S. S. Ferro, Austin Kahng, Jessica A. Xavier, Andre M. Dixon, Jessica R. Vrudhula, Uma Nichitiu, Anne-Sarah Rosado, Daniele Wee, Tse-Luen Pedmale, Ullas V. Cheadle, Lucas Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title | Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title_full | Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title_fullStr | Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title_full_unstemmed | Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title_short | Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| title_sort | oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534756/ https://www.ncbi.nlm.nih.gov/pubmed/36171430 http://dx.doi.org/10.1038/s41593-022-01170-x |
| work_keys_str_mv | AT augusteyohanss oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT ferroaustin oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT kahngjessicaa oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT xavierandrem oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT dixonjessicar oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT vrudhulauma oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT nichitiuannesarah oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT rosadodaniele oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT weetseluen oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT pedmaleullasv oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice AT cheadlelucas oligodendrocyteprecursorcellsengulfsynapsesduringcircuitremodelinginmice |