The evolutionary dynamics of extrachromosomal DNA in human cancers

Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance—random identity by descent—is poorly understood. Also unclear is the impact of ecDNA on somati...

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Detalles Bibliográficos
Autores principales: Lange, Joshua T., Rose, John C., Chen, Celine Y., Pichugin, Yuriy, Xie, Liangqi, Tang, Jun, Hung, King L., Yost, Kathryn E., Shi, Quanming, Erb, Marcella L., Rajkumar, Utkrisht, Wu, Sihan, Taschner-Mandl, Sabine, Bernkopf, Marie, Swanton, Charles, Liu, Zhe, Huang, Weini, Chang, Howard Y., Bafna, Vineet, Henssen, Anton G., Werner, Benjamin, Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534767/
https://www.ncbi.nlm.nih.gov/pubmed/36123406
http://dx.doi.org/10.1038/s41588-022-01177-x

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