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COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol
INTRODUCTION: The COVID-19 pandemic has led to concerns about potential adverse pregnancy outcomes associated with infection, resulting in intensive research. Numerous studies have attempted to examine whether COVID-19 is associated with an increased risk of pregnancy loss. However, studies and revi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534774/ https://www.ncbi.nlm.nih.gov/pubmed/36192094 http://dx.doi.org/10.1136/bmjopen-2022-065588 |
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author | Campbell, Jennifer Williams, Rachael Harley, Mia Bhaskaran, Krishnan |
author_facet | Campbell, Jennifer Williams, Rachael Harley, Mia Bhaskaran, Krishnan |
author_sort | Campbell, Jennifer |
collection | PubMed |
description | INTRODUCTION: The COVID-19 pandemic has led to concerns about potential adverse pregnancy outcomes associated with infection, resulting in intensive research. Numerous studies have attempted to examine whether COVID-19 is associated with an increased risk of pregnancy loss. However, studies and reviews to date have drawn differing conclusions. The aim of this systematic review is to provide a summary of all quantitative research on the relationship between pregnancy loss and COVID-19 infection and, if appropriate, to synthesise the evidence into an overall effect estimate. METHODS AND ANALYSIS: Three publication databases (Embase, PubMed and Cochrane) and four preprint databases (medRxiv, Lancet Preprint, Gates Open Research and Wellcome Open Research) will be searched. Boolean logic will be used to combine terms associated with pregnancy loss and COVID-19. The population of interest are pregnant women. Retrieved results will be assessed in two phases: (1) abstract screening and (2) full text evaluation. All studies which compare pregnancy loss outcomes in women who had COVID-19 versus those who did not quantitatively will be included. Narrative and non-English studies will be excluded. Two reviewers will screen independently, with results compared and discrepancies resolved by the study team. Study quality and risk of bias will be assessed using a quality appraisal tool. Results will be summarised descriptively and where possible synthesised in a meta-analysis. ETHICS AND DISSEMINATION: This systematic review requires no ethical approval. This review will be published in a peer-reviewed journal and provide an important update in a rapidly evolving field of research. PROSPERO REGISTRATION NUMBER: CRD42022327437. |
format | Online Article Text |
id | pubmed-9534774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-95347742022-10-06 COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol Campbell, Jennifer Williams, Rachael Harley, Mia Bhaskaran, Krishnan BMJ Open Epidemiology INTRODUCTION: The COVID-19 pandemic has led to concerns about potential adverse pregnancy outcomes associated with infection, resulting in intensive research. Numerous studies have attempted to examine whether COVID-19 is associated with an increased risk of pregnancy loss. However, studies and reviews to date have drawn differing conclusions. The aim of this systematic review is to provide a summary of all quantitative research on the relationship between pregnancy loss and COVID-19 infection and, if appropriate, to synthesise the evidence into an overall effect estimate. METHODS AND ANALYSIS: Three publication databases (Embase, PubMed and Cochrane) and four preprint databases (medRxiv, Lancet Preprint, Gates Open Research and Wellcome Open Research) will be searched. Boolean logic will be used to combine terms associated with pregnancy loss and COVID-19. The population of interest are pregnant women. Retrieved results will be assessed in two phases: (1) abstract screening and (2) full text evaluation. All studies which compare pregnancy loss outcomes in women who had COVID-19 versus those who did not quantitatively will be included. Narrative and non-English studies will be excluded. Two reviewers will screen independently, with results compared and discrepancies resolved by the study team. Study quality and risk of bias will be assessed using a quality appraisal tool. Results will be summarised descriptively and where possible synthesised in a meta-analysis. ETHICS AND DISSEMINATION: This systematic review requires no ethical approval. This review will be published in a peer-reviewed journal and provide an important update in a rapidly evolving field of research. PROSPERO REGISTRATION NUMBER: CRD42022327437. BMJ Publishing Group 2022-10-03 /pmc/articles/PMC9534774/ /pubmed/36192094 http://dx.doi.org/10.1136/bmjopen-2022-065588 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Campbell, Jennifer Williams, Rachael Harley, Mia Bhaskaran, Krishnan COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title | COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title_full | COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title_fullStr | COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title_full_unstemmed | COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title_short | COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
title_sort | covid-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534774/ https://www.ncbi.nlm.nih.gov/pubmed/36192094 http://dx.doi.org/10.1136/bmjopen-2022-065588 |
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