Cargando…
Phase separation of low-complexity domains in cellular function and disease
In this review, we discuss the ways in which recent studies of low-complexity (LC) domains have challenged our understanding of the mechanisms underlying cellular organization. LC sequences, long believed to function in the absence of a molecular structure, are abundant in the proteomes of all eukar...
Autores principales: | Lee, Jiwon, Cho, Hana, Kwon, Ilmin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534829/ https://www.ncbi.nlm.nih.gov/pubmed/36175485 http://dx.doi.org/10.1038/s12276-022-00857-2 |
Ejemplares similares
-
Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription
por: Kim, Ga Hye, et al.
Publicado: (2021) -
Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS
por: Jo, Yunhee, et al.
Publicado: (2022) -
Assemblages: Functional units formed by cellular phase separation
por: Toretsky, Jeffrey A., et al.
Publicado: (2014) -
Modulation of I
(Ks) channel–PIP(2) interaction by PRMT1 plays a critical role in the control of cardiac repolarization
por: An, Xue, et al.
Publicado: (2022) -
Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
por: Monahan, Zachary, et al.
Publicado: (2017)