Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle

Effective protein import from cytosol is critical for mitochondrial functions and metabolic regulation. We describe here the mammalian muscle-specific and systemic consequences to disrupted mitochondrial matrix protein import by targeted deletion of the mitochondrial HSP70 co-chaperone GRPEL1. Muscl...

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Detalles Bibliográficos
Autores principales: Neupane, Nirajan, Rajendran, Jayasimman, Kvist, Jouni, Harjuhaahto, Sandra, Hu, Bowen, Kinnunen, Veijo, Yang, Yang, Nieminen, Anni I., Tyynismaa, Henna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534917/
https://www.ncbi.nlm.nih.gov/pubmed/36198903
http://dx.doi.org/10.1038/s42003-022-04034-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534917/
https://www.ncbi.nlm.nih.gov/pubmed/36198903
http://dx.doi.org/10.1038/s42003-022-04034-z

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