Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve as a model of prematur...

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Detalles Bibliográficos
Autores principales: Sasako, Takayoshi, Umehara, Toshihiro, Soeda, Kotaro, Kaneko, Kazuma, Suzuki, Miho, Kobayashi, Naoki, Okazaki, Yukiko, Tamura-Nakano, Miwa, Chiba, Tomoki, Accili, Domenico, Kahn, C. Ronald, Noda, Tetsuo, Asahara, Hiroshi, Yamauchi, Toshimasa, Kadowaki, Takashi, Ueki, Kohjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535008/
https://www.ncbi.nlm.nih.gov/pubmed/36198696
http://dx.doi.org/10.1038/s41467-022-33008-2

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