The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the physiological status of the parent cell and play...

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Autores principales: Wang, Xinyi, Huang, Jing, Chen, Wenjie, Li, Genpeng, Li, Zhihui, Lei, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535014/
https://www.ncbi.nlm.nih.gov/pubmed/36138197
http://dx.doi.org/10.1038/s12276-022-00855-4
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author Wang, Xinyi
Huang, Jing
Chen, Wenjie
Li, Genpeng
Li, Zhihui
Lei, Jianyong
author_facet Wang, Xinyi
Huang, Jing
Chen, Wenjie
Li, Genpeng
Li, Zhihui
Lei, Jianyong
author_sort Wang, Xinyi
collection PubMed
description Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the physiological status of the parent cell and play an essential role in cell–cell communication. Exosomal proteins can regulate tumor development, including tumor-related immune regulation, microenvironment reconstruction, angiogenesis, epithelial–mesenchymal transition, metastasis, etc. The features of exosomal proteins can provide insight into exosome generation, targeting, and biological function and are potential sources of markers for cancer diagnosis, prognosis, and treatment. Here, we summarize the effects of exosomal proteins on cancer biology, the latest progress in the application of exosomal proteins in cancer diagnosis and prognosis, and the potential contribution of exosomal proteins in cancer therapeutics and vaccines.
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spelling pubmed-95350142022-10-20 The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer Wang, Xinyi Huang, Jing Chen, Wenjie Li, Genpeng Li, Zhihui Lei, Jianyong Exp Mol Med Review Article Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the physiological status of the parent cell and play an essential role in cell–cell communication. Exosomal proteins can regulate tumor development, including tumor-related immune regulation, microenvironment reconstruction, angiogenesis, epithelial–mesenchymal transition, metastasis, etc. The features of exosomal proteins can provide insight into exosome generation, targeting, and biological function and are potential sources of markers for cancer diagnosis, prognosis, and treatment. Here, we summarize the effects of exosomal proteins on cancer biology, the latest progress in the application of exosomal proteins in cancer diagnosis and prognosis, and the potential contribution of exosomal proteins in cancer therapeutics and vaccines. Nature Publishing Group UK 2022-09-22 /pmc/articles/PMC9535014/ /pubmed/36138197 http://dx.doi.org/10.1038/s12276-022-00855-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Xinyi
Huang, Jing
Chen, Wenjie
Li, Genpeng
Li, Zhihui
Lei, Jianyong
The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title_full The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title_fullStr The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title_full_unstemmed The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title_short The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
title_sort updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535014/
https://www.ncbi.nlm.nih.gov/pubmed/36138197
http://dx.doi.org/10.1038/s12276-022-00855-4
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