Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer

Phospholipase D (PLD) is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The inhibitor enhanced apoptosis in colorectal cancer...

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Detalles Bibliográficos
Autores principales: Hwang, Won Chan, Song, Doona, Lee, Hyesung, Oh, Changmok, Lim, Seong Hun, Bae, Hyeon Jeong, Kim, Nam Doo, Han, Gyoonhee, Min, Do Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535023/
https://www.ncbi.nlm.nih.gov/pubmed/36131027
http://dx.doi.org/10.1038/s12276-022-00853-6

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