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The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review

Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to...

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Autores principales: Amini, Mohammad Amin, Karimi, Masoud, Talebi, Seyed Saman, Piri, Hossein, Karimi, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535111/
https://www.ncbi.nlm.nih.gov/pubmed/36245774
http://dx.doi.org/10.4068/cmj.2022.58.3.91
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author Amini, Mohammad Amin
Karimi, Masoud
Talebi, Seyed Saman
Piri, Hossein
Karimi, Jamshid
author_facet Amini, Mohammad Amin
Karimi, Masoud
Talebi, Seyed Saman
Piri, Hossein
Karimi, Jamshid
author_sort Amini, Mohammad Amin
collection PubMed
description Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-α and NF-κB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-κB pathway in the cells, furthermore, TNF-α can arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-α and NF-κB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder.
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spelling pubmed-95351112022-10-14 The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review Amini, Mohammad Amin Karimi, Masoud Talebi, Seyed Saman Piri, Hossein Karimi, Jamshid Chonnam Med J Review Article Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-α and NF-κB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-κB pathway in the cells, furthermore, TNF-α can arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-α and NF-κB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder. Chonnam National University Medical School 2022-09 2022-09-23 /pmc/articles/PMC9535111/ /pubmed/36245774 http://dx.doi.org/10.4068/cmj.2022.58.3.91 Text en © Chonnam Medical Journal, 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Amini, Mohammad Amin
Karimi, Masoud
Talebi, Seyed Saman
Piri, Hossein
Karimi, Jamshid
The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title_full The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title_fullStr The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title_full_unstemmed The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title_short The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
title_sort association of oxidative stress and reactive oxygen species modulator 1 (romo1) with infertility: a mini review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535111/
https://www.ncbi.nlm.nih.gov/pubmed/36245774
http://dx.doi.org/10.4068/cmj.2022.58.3.91
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