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CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein

BACKGROUND: Cancer immune escape is a main obstacle in designing effective anticancer therapeutic approaches. Our work was aimed to explore the function of cullin 3 (CUL3) in ovarian cancer cell immune escape and chemosensitivity. METHOD: Gain and loss of function assays were conducted to investigat...

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Detalles Bibliográficos
Autores principales:	Dong, Min, Qian, Min, Ruan, Zhengyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535172/ https://www.ncbi.nlm.nih.gov/pubmed/36198437 http://dx.doi.org/10.1136/jitc-2022-005270

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