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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy

BACKGROUND: Current immunotherapies still have limited successful rates among cancers. It is now recognized that T cell functional state in the tumor microenvironment (TME) is a key determinant for effective antitumor immunity and immunotherapy. In addition to exhaustion, cellular senescence in tumo...

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Detalles Bibliográficos
Autores principales:	Liu, Xia, Si, Fusheng, Bagley, David, Ma, Feiya, Zhang, Yuanqin, Tao, Yan, Shaw, Emily, Peng, Guangyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535198/ https://www.ncbi.nlm.nih.gov/pubmed/36192086 http://dx.doi.org/10.1136/jitc-2022-005020

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