Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin

PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for drug development. However, most PROTACs generated lack cell-type selectivity and are poorly soluble in water. To address this d...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Li, Ling, Wang, Xia, Liu, Huimin, Zhang, Yibin, Xie, Tiantian, Zhang, Hui, Li, Xiaodong, Peng, Tianhuan, Sun, Xing, Dai, Jing, Liu, Jing, Wu, Wencan, Ye, Mao, Tan, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535278/
https://www.ncbi.nlm.nih.gov/pubmed/36250201
http://dx.doi.org/10.1016/j.omtn.2022.09.008

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