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TRPC6 mediates high glucose-induced mitochondrial fission through activation of CDK5 in cultured human podocytes
Mitochondrial abnormalities contribute to the development of diabetic nephropathy (DN). However, the precise mechanisms of mitochondrial dysfunction in DN remain unclear. Transient receptor potential canonical channel-6 (TRPC6), a non-selective cation channel permeable to Ca(2+), has been shown to r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535336/ https://www.ncbi.nlm.nih.gov/pubmed/36213244 http://dx.doi.org/10.3389/fphys.2022.984760 |